Cellular heterogeneity and clonal hematopoiesis of immune system cells in atherosclerosis

Recent studies in single cell RNA sequencing have improved understanding of the structure immune subpopulation atherosclerosis. With help novel technologies, new subpopulations cells involved atherosclerosis been identified. In addition, a following relatively common and strong cardiovascular risk factor has emerged: clonal hematopoiesis indeterminate potential resulting from accumulation somatic mutations during life with appearance populations mutant leukocyte clones. Individuals this condition are at high for complications such as myocardial infarction stroke, regardless conventional factors. This review highlights latest data on study cellular heterogeneity system atherosclerosis, well role its development.